The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.

@article{Hickman2011TheHM,
  title={The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae.},
  author={Mark J Hickman and Dan Spatt and Fred Winston},
  journal={Genetics},
  year={2011},
  volume={188 2},
  pages={325-38}
}
We have studied hypoxic induction of transcription by studying the seripauperin (PAU) genes of Saccharomyces cerevisiae. Previous studies showed that PAU induction requires the depletion of heme and is dependent upon the transcription factor Upc2. We have now identified additional factors required for PAU induction during hypoxia, including Hog1, a mitogen-activated protein kinase (MAPK) whose signaling pathway originates at the membrane. Our results have led to a model in which heme and… CONTINUE READING
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Functional profiling of the Saccharomyces cerevisiae genome

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