The History of Testosterone and the Evolution of its Therapeutic Potential.

  title={The History of Testosterone and the Evolution of its Therapeutic Potential.},
  author={Abraham Morgentaler and Abdulmaged M Traish},
  journal={Sexual medicine reviews},
INTRODUCTION Testosterone therapy has been controversial since its synthesis in the 1930s to the present day. Testosterone's history provides depth and context for current controversies. AIM To review the history of testosterone therapy from its initial synthesis in the 1930s to the modern day. METHODS Expert review of the literature. MAIN OUTCOME MEASURES Impactful events in the history of testosterone. RESULTS By the 1940s there was already a fascinating literature that described the… Expand
8 Citations
Hypogonadism management and cardiovascular health
The current evidence regarding the cardiovascular safety of testosterone therapy for the management of hypogonadism is summarized, as well as the proposed mechanisms that may explain testosterone’s underlying effects. Expand
The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective
This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment. Expand
A qualitative exploration of South African men’s perceived effects of Androgen Deprivation Therapy (ADT) as a treatment for advanced prostate cancer
Abstract Objective We undertake qualitative research with men treated in a Pretoria, South Africa Oncology clinic to address men’s self-reported experiences on androgen deprivation therapy (ADT).Expand
Current use of testosterone therapy in LGBTQ populations
Although TT is an effective treatment for many patients, there has been an increase in the illegitimate acquisition of TT in recent years and non-judicious prescribing and lack of physician surveillance increases the risk of unintended side effects and potential serious health consequences. Expand
Opiates Possibly Boosted Human Civilization
A possibility indicating that opiates promoted civilization processes among early humans is discussed, suggesting that modern humans might have inherited the positive impact of opiates on early humans as a biological propensity for using opioids. Expand
Reverse intermittent androgen deprivation therapy: Prostate cancer and hypopituitarism
A large number of patients receiving testosterone replacement therapy in the context of untreated prostate cancer have indicated that they believe that the therapy should be continued for at least two years after initial treatment with testosterone. Expand
Testosterone replacement therapy reduces biochemical recurrence after radical prostatectomy
To evaluate risk of prostate cancer biochemical recurrence (BCR) after radical prostatectomy (RP) in men receiving vs not receiving testosterone replacement therapy (TRT), data are presented on patients receiving or not receiving TRT. Expand


The long and tortuous history of the discovery of testosterone and its clinical application.
  • A. Morales
  • Medicine, Psychology
  • The journal of sexual medicine
  • 2013
The history of testosterone discovery, synthesis, and introduction into the therapeutic armamentarium is an outstanding example of human curiosity, ingenuity, greed, and skepticism. Expand
A brief history of testosterone.
The history of testosterone in the context of medical and scientific developments is explored, finding the effects of the powerful hormone testosterone continue to inspire research and controversy 65 years later. Expand
The history of synthetic testosterone.
Clinical uses include hypogonadism growth stimulation in puberty treatment of trauma male fertility regulation and retardation of the aging process, and treatment of women with testosterone has been used for hormone-dependent breast tumors as well as for intensifying the female libido. Expand
Testosterone deficiency: a historical perspective
Testicular transplantation is being refined by stem cell research and germ cell transplantation, and research concentrated on the chemical modification of androgens in order to emphasize their anabolic effects. Expand
Testosterone and prostate cancer: an historical perspective on a modern myth.
There is not now-nor has there ever been-a scientific basis for the belief that testosterone (T) causes prostate cancer (pCA) growth, and this historical perspective reveals that this modern myth is a modern myth. Expand
Use of Testosterone Propionate and Estrogenic Substance in Treatment of Essential Hypertension, Angina Pectoris and Peripheral Vascular Disease
The effect of the sex hormones in cardiovascular disease has been the subject of relatively few clinical investigations, but several reports have been published indicating that these substances may find a useful place in the management of certain vascular disorders. Expand
Shifting the paradigm of testosterone and prostate cancer: the saturation model and the limits of androgen-dependent growth.
There is a limit to the ability of androgens to stimulate PCa growth, and a Saturation Model based on androgen-AR binding provides a satisfactory conceptual framework to account for the dramatic effects seen with castration as well as the minor impact of T administration in noncastrated men. Expand
The Treatment of Angina Pectoris with Testosterone Propionate
Recent studies indicate that androgenic treatment may be of considerable therapeutic value in angina pectoris, but in some instances there was gradual recurrence of symptoms on discontinuation of treatment and in a few there was questionable improvement or none whatsoever. Expand
Testosterone therapy in men with untreated prostate cancer.
Testosterone therapy in men with untreated prostate cancer was not associated with prostate cancer progression in the short to medium term, consistent with the saturation model, ie maximal prostate cancer growth is achieved at low androgen concentrations. Expand
The dark side of testosterone deficiency: III. Cardiovascular disease.
In view of the emerging evidence suggesting that androgen deficiency is a risk factor for CVD, androgen replacement therapy could potentially reduce CVD risk in hypogonadal men. Expand