The History of Pancreas Transplantation: Past, Present and Future

@article{Squifflet2008TheHO,
  title={The History of Pancreas Transplantation: Past, Present and Future},
  author={J. Squifflet and R. Gruessner and D. Sutherland},
  journal={Acta Chirurgica Belgica},
  year={2008},
  volume={108},
  pages={367 - 378}
}
Abstract The first attempt to cure type 1 diabetes by pancreas transplantation was done at the University of Minnesota, in Minneapolis, on December 17, 1966, followed by a series of whole pancreas transplantation. Due to the lack of potent immunosuppressive drugs, rejections and infections, it was concluded that pancreas was less antigenic than the kidney which was less antigenic than the duodenum. It opened the door to a period, between the mid 70’s to mid 80’s where only segmental pancreatic… Expand
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References

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TLDR
Patient and graft survival rates have significantly improved over time as surgical techniques and immunosuppressive protocols have evolved, and quality of life studies showed significant gains after the transplant in all recipient categories. Expand
Simultaneous pancreas-kidney transplantation at the University of Wisconsin.
TLDR
The most important recent improvement in immunosuppression is the use of mycophenolate mofetil, which has dramatically reduced rejection and PDC leaks, the principal and potentially most devastating complication of SPK transplantation, are rapidly diagnosed and treated expeditiously. Expand
Experience with Simultaneous Pancreas‐kidney Transplantation
TLDR
In conclusion, renal transplantation in concert with pancreas transplantation has a dramatic positive impact on Pancreas allograft survival and appears to be the treatment of choice for Type I diabetic patients. Expand
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Pancreatico-duodenal allotransplantation alone is now planned for juvenile onset diabetics who have significant but not terminal renal nephropathy if the characteristic vascular disease of diabetes mellitus can be altered by a pancreatic allograft, then this will become one of the most commonly performed transplant procedures. Expand
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TLDR
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TLDR
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TLDR
Pancreatic transplantation can maintain blood glucose and insulin at normal levels for extended periods of time, however, it does not reverse such complications as advanced retinopathy or atherosclerosis. Expand
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TLDR
The spleen has been transplanted with the pancreas mainly for technical reasons, and this technique should have further trials in spite of the fact that delayed graft splenectomy became necessary in two recipients to treat graft induced hematologic complications. Expand
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Three cases of human pancreaticoduodenal allografting are reported. One of the three patients showed no rejection of her transplanted pancreas for a period of ten months at which time she was killedExpand
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