The History of DES, Lessons to be Learned

  title={The History of DES, Lessons to be Learned},
  author={Marieke Veurink and Marlies E T A Koster and Lolkje T.W. de Jong-van den. Berg},
  journal={Pharmacy World and Science},
Since the 1940s, diaethylstilbestrol (DES) has been used by millions of pregnant women to prevent miscarriages and many other disorders in pregnancy. In 1971, it became clear that this apparently innocent treatment proved to be a time bomb for the infants exposed to DES during the first trimester of pregnancy. DES is now associated with an increased risk of breast cancer, clear cell adenocarcinoma (CCAC) of the vagina and cervix, and reproductive anomalies. This article summarises the potential… CONTINUE READING

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