The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice.

@article{Brinkmeier2015TheHM,
  title={The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice.},
  author={Michelle L. Brinkmeier and Krista A. Geister and Morgan A Jones and Meriam Waqas and Ivan P Maillard and Sally A Camper},
  journal={Biology of reproduction},
  year={2015},
  volume={93 5},
  pages={121}
}
Chromatin remodeling influences gene expression in developing and adult organisms. Active and repressive marks of histone methylation dictate the embryonic expression boundaries of developmentally regulated genes, including the Hox gene cluster. Drosophila ash1 (absent, small or homeotic discs 1) gene encodes a histone methyltransferase essential for regulation of Hox gene expression that interacts genetically with other members of the trithorax group (TrxG). While mammalian members of the… CONTINUE READING