The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

  title={The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα},
  author={Feng Li and Guogen Mao and Dan Tong and Xingang Li and Liya Gu and Wei Yang and Guo-Min Li},
DNA mismatch repair (MMR) ensures replication fidelity by correcting mismatches generated during DNA replication. Although human MMR has been reconstituted in vitro, how MMR occurs in vivo is unknown. Here, we show that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα (hMSH2-hMSH6) onto chromatin through direct interactions with the hMSH6 PWWP domain. The abundance of H3K36me3 in G1 and early S phases ensures that hMutSα is enriched on… CONTINUE READING
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