The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

@article{Li2013TheHM,
  title={The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα},
  author={Feng Li and Guogen Mao and Dan Tong and Xingang Li and Liya Gu and Wei Yang and Guo-Min Li},
  journal={Cell},
  year={2013},
  volume={153},
  pages={590-600}
}
DNA mismatch repair (MMR) ensures replication fidelity by correcting mismatches generated during DNA replication. Although human MMR has been reconstituted in vitro, how MMR occurs in vivo is unknown. Here, we show that an epigenetic histone mark, H3K36me3, is required in vivo to recruit the mismatch recognition protein hMutSα (hMSH2-hMSH6) onto chromatin through direct interactions with the hMSH6 PWWP domain. The abundance of H3K36me3 in G1 and early S phases ensures that hMutSα is enriched on… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 126 extracted citations

Histone profiles in cancer.

Pharmacology & therapeutics • 2015
View 15 Excerpts
Highly Influenced

SETting the Stage for Cancer Development: SETD2 and the Consequences of Lost Methylation.

Cold Spring Harbor perspectives in medicine • 2017
View 5 Excerpts
Highly Influenced

DNA repair mechanisms and their clinical impact in glioblastoma.

Mutation research. Reviews in mutation research • 2016
View 12 Excerpts
Highly Influenced

Microsatellite instability: an update

Archives of Toxicology • 2015
View 13 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Interplay between mismatch repair and chromatin assembly.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 4 Excerpts
Highly Influenced

Role of DNA mismatch repair defects in the pathogenesis of human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2003
View 4 Excerpts
Highly Influenced

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

The New England journal of medicine • 2012
View 5 Excerpts
Highly Influenced

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

Nature Structural &Molecular Biology • 2010
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…