The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3

@inproceedings{Albert2013TheHD,
  title={The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3},
  author={Mareike Albert and Sandra U. Schmitz and Susanne Marije Kooistra and Martina Malatesta and Cristina Morales Torres and Jens C Rekling and Jens Vilstrup Johansen and Iratxe Abarrategui and Kristian Helin},
  booktitle={PLoS genetics},
  year={2013}
}
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized… CONTINUE READING
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