The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

Abstract

SIRT6 is a member of a highly conserved family of NAD(+)-dependent deacetylases with various roles in metabolism, stress resistance, and life span. SIRT6-deficient mice develop normally but succumb to a lethal hypoglycemia early in life; however, the mechanism underlying this hypoglycemia remained unclear. Here, we demonstrate that SIRT6 functions as a… (More)
DOI: 10.1016/j.cell.2009.12.041

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