The Histone Deacetylase Inhibitor Sodium Butyrate Induces DNA Topoisomerase II Expression and Confers Hypersensitivity to Etoposide in Human Leukemic Cell Lines 1

@inproceedings{Kurz2001TheHD,
  title={The Histone Deacetylase Inhibitor Sodium Butyrate Induces DNA Topoisomerase II Expression and Confers Hypersensitivity to Etoposide in Human Leukemic Cell Lines 1},
  author={Ebba U. Kurz and Sara E. Wilson and Kelly B. Leader and Brante P. Sampey and William P. Allan and Jack C. Yalowich and David J. Kroll},
  year={2001}
}
The differentiating agent and histone deacetylase inhibitor, sodium butyrate (NaB), was shown previously to cause a transient, 3–17-fold induction of human DNA topoisomerase II (topo II ) gene promoter activity and a 2-fold increase in topo II protein early in monocytic differentiation of HL-60 cells. This observation has now been extended to other short chain fatty acids and aromatic butyrate analogues, and evidence is presented that human topo II promoter induction correlates closely with… CONTINUE READING

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 128 HDAC Inhibitors and topo II

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