The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats

@inproceedings{Eissa2018TheHH,
  title={The Histamine H3 Receptor Antagonist DL77 Ameliorates MK801-Induced Memory Deficits in Rats},
  author={Nermin A. M. Eissa and Nadia A Khan and Shreesh Kumar Ojha and Dorota Łażewska and Katarzyna Kie{\'c}-Kononowicz and Bassem Sadek},
  booktitle={Front. Neurosci.},
  year={2018}
}
The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tested in an inhibitory passive avoidance paradigm (PAP) and novel object recognition (NOR) task in adult male rats, using donepezil (DOZ) as a standard drug. Acute systemic… CONTINUE READING
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