The Hippocampal‐Dentate Complex in Temporal Lobe Epilepsy

@article{Scheibel1974TheHC,
  title={The Hippocampal‐Dentate Complex in Temporal Lobe Epilepsy},
  author={Madge E. Scheibel and Paul H. Crandall and Arnold B. Scheibel},
  journal={Epilepsia},
  year={1974},
  volume={15}
}
The hippocampal‐dentate complex of 11 patients operated for temporal lobe epilepsy was studied by variations of the Golgi method. A spectrum of changes in hippocampal pyramids and dentate granular cells was found, ranging from minor pathology along single dendrites to massive degenerative changes involving many neurons, and culminating in cell death. Loss of dendritic spines and development of nodules along dendritic shafts were the mildest pathological changes. That pathology could be highly… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Structural Substrates of Seizure Foci in the Human Temporal Lobe: A Combined Electrophysiological Optical Microscopic and Ultrastructural Study
TLDR
Structural substrates of seizure foci in the human temporal lobe are discussed, which can result from either chronic injury, stemming from the initial hypoxic insult eventuated in hippocampal sclerosis, or from damage incident to the seizures. Expand
UNUSUALLY SEVERE LESIONS IN THE BRAIN FOLLOWING STATUS EPILEPTICUS
TLDR
The case which will be reported in this paper has already been briefly mentioned in a previous communication and seems to be of sufficient importance with regard to several problems concerning temporal lobe epilepsy to justify its publication as an individual case. Expand
Genetic and Related Aetiological Factors in Temporal Lobe Epilepsy
TLDR
Clinico‐pathological observations regarding aetiology are reported in two large series of patients submitted to operation for chronic non‐tumorous drug‐resistant temporal lobe epilepsy, finding that such other factors as difficult birth, post‐natal head injury, or other miscellaneous illnesses in childhood do not appear to have been significant factors influencing epilepsy in these four groups of patients. Expand
Incisural sclerosis and temporal lobe seizures produced by hippocampal herniation at birth.
TLDR
In a series of 157 cases of seizures originating in the temporal lobe, the anatomical location and pathology of the abnormalities which were found on surgical exploration and cortical excision suggested that compression or anoxia during birth or infancy was the cause. Expand
ETIOLOGY AND PATHOGENESIS OF TEMPORAL LOBE EPILEPSY.
TLDR
The pathological findings in 100 consecutive patients with epilepsy submitted to a unilateral temporal lobectomy are recorded, and their origin and their significance are discussed. Expand
CLINICAL APPLICATIONS OF STUDIES ON STEREOTACTICALLY IMPLANTED ELECTRODES IN TEMPORAL-LOBE EPILEPSY.
TLDR
Electroencephalography was necessary to provide a confirmatory test and a reliable means to distinguish these states of seizures, now termed temporal-lobe epilepsy, and it is established that at least two-thirds of patients have complete or very good relief from seizures. Expand
Synaptic loci on visual cortical neurons of the rabbit: the specific afferent radiation.
TLDR
The study underlines the sensitivity of postsynaptic components to changes in level of presynaptic function and focuses attention upon the dendrite spine as an accurate index of presyaptic geometry, thereby providing a more effective measure of terminal axonal patterns throughout the nervous system. Expand
Pattern and field in cortical structure: The rabbit
TLDR
The data indicate that neurons with extra‐cortically projecting axons (long axons) invariably possess spine‐rich dendrites forming domains with remarkably regular horizontal parameters (i.e. modular domains), and cells with axons limited to intra-cortical paths are characterized by spine‐poor or spine‐free dendrite forming domains which are highly variable in size and shape. Expand
Stellate cells of the rat parietal cortex
  • A. Peters
  • Biology, Medicine
  • The Journal of comparative neurology
  • 1971
TLDR
Perikaryal cytoplasm is thick, the granular endoplasmic reticulum is often arranged in parallel arrays, and the type of synapse with a side cleft and a prominent postsynaptic density is most common. Expand
L'exploration chirurgicale stéréotaxique du lobe temporal dans l'épilepsie temporale.
This study consists of two parts: (1) an anatomical part which treats of the system of reference which the authors have adopted for stereotaxic interventions on the most important temporalExpand
...
1
2
3
4
5
...