The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.

@article{Tremblay2014TheHT,
  title={The Hippo transducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation.},
  author={Annie M. Tremblay and Edoardo Missiaglia and Giorgio Giacomo Galli and Simone Hettmer and Roby Urcia and Matteo Carrara and Robert N. Judson and Khin Thway and Gema Nadal and Joanna L Selfe and Graeme I. Murray and Raffaele Adolfo Calogero and Cosimo de Bari and Peter S Zammit and Mauro Delorenzi and Amy J. Wagers and Janet M Shipley and Henning Wackerhage and Fernando D Camargo},
  journal={Cancer cell},
  year={2014},
  volume={26 2},
  pages={273-87}
}
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. Via its transcriptional program with TEAD1, YAP1 directly regulates several major hallmarks of ERMS. YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS… CONTINUE READING
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