The Hippo size control pathway--ever expanding.

@article{Lin2013TheHS,
  title={The Hippo size control pathway--ever expanding.},
  author={Jane I. Lin and Carole L.C. Poon and Kieran F. Harvey},
  journal={Science signaling},
  year={2013},
  volume={6 259},
  pages={pe4}
}
An important regulator of organ size and tumorigenesis is the Hippo pathway. Recent studies have unveiled increasing complexity in regulation of Hippo pathway activity at the level of the oncoprotein Yes-associated protein (YAP). The protein tyrosine phosphatase 14 (PTPN14, known as Pez in Drosophila) was identified as a protein that antagonizes the function of the key Hippo pathway protein YAP by promoting its cytoplasmic localization under high cell density conditions. In Drosophila, Pez was… CONTINUE READING
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