The Hippo signaling pathway provides novel anti-cancer drug targets

@inproceedings{Bae2017TheHS,
  title={The Hippo signaling pathway provides novel anti-cancer drug targets},
  author={June Sung Bae and Sun Mi Kim and Ho Joung Lee},
  booktitle={Oncotarget},
  year={2017}
}
The Hippo signaling pathway plays a crucial role in cell proliferation, apoptosis, differentiation, and development. Major effectors of the Hippo signaling pathway include the transcriptional co-activators Yes-associated protein 1 (YAP) and WW domain-containing transcription regulator protein 1 (TAZ). The transcriptional activities of YAP and TAZ are affected by interactions with proteins from many diverse signaling pathways as well as responses to the external environment. High YAP and TAZ… CONTINUE READING
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