The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1

@article{Hansen2015TheHP,
  title={The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORC1},
  author={Carsten Gram Hansen and Yuen Lam Dora Ng and W M Lam and Steven W. Plouffe and Kun Liang Guan},
  journal={Cell Research},
  year={2015},
  volume={25},
  pages={1299-1313}
}
YAP and TAZ are transcriptional co-activators and function as the major effectors of the Hippo tumor suppressor pathway, which controls cell growth, tissue homeostasis, and organ size. Here we show that YAP/TAZ play an essential role in amino acid-induced mTORC1 activation, particularly under nutrient-limiting conditions. Mechanistically, YAP/TAZ act via the TEAD transcription factors to induce expression of the high-affinity leucine transporter LAT1, which is a heterodimeric complex of SLC7A5… CONTINUE READING
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