The Hippo pathway and human cancer

  title={The Hippo pathway and human cancer},
  author={Kieran F. Harvey and Xiaomeng Zhang and David M Thomas},
  journal={Nature Reviews Cancer},
The Hippo pathway controls organ size in diverse species, whereas pathway deregulation can induce tumours in model organisms and occurs in a broad range of human carcinomas, including lung, colorectal, ovarian and liver cancer. Despite this, somatic or germline mutations in Hippo pathway genes are uncommon, with only the upstream pathway gene neurofibromin 2 (NF2) recognized as a bona fide tumour suppressor gene. In this Review, we appraise the evidence for the Hippo pathway as a cancer… CONTINUE READING
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