The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*

  title={The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCF$\beta$-TrCP E3 Ligase*},
  author={Chenying Liu and Zhengyu Zha and Xin Zhou and Heng Zhang and Wei Huang and Di Zhao and Tingting Li and Siew Wee Chan and Chun Jye Lim and Wanjin Hong and Shimin Zhao and Yue Xiong and Qunying Lei and Kun Liang Guan},
  journal={The Journal of Biological Chemistry},
  pages={37159 - 37169}
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by the SCF/CRL1β-TrCP E3 ligase. The interaction between TAZ and β-TrCP is regulated by the Hippo pathway. Phosphorylation of a phosphodegron in… 

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