The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*

@article{Liu2010TheHT,
  title={The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCF$\beta$-TrCP E3 Ligase*},
  author={Chenying Liu and Zhengyu Zha and Xin Zhou and Heng Zhang and Wei Huang and Di Zhao and Tingting Li and Siew Wee Chan and Chun Jye Lim and Wanjin Hong and Shimin Zhao and Yue Xiong and Qunying Lei and Kun Liang Guan},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={37159 - 37169}
}
The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by the SCF/CRL1β-TrCP E3 ligase. The interaction between TAZ and β-TrCP is regulated by the Hippo pathway. Phosphorylation of a phosphodegron in… 

Figures from this paper

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TLDR
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TLDR
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DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins

TLDR
Evidence is provided that DUB3 proteins regulate YAP/TAZ activity by controlling the stability of the E3 ligase ITCH, the LATS kinases and the AMOT family proteins.

PARD 3 induces TAZ activation and cell growth by promoting LATS 1 and PP 1 interaction

TLDR
This study indicates a potential molecular basis for cell growth-promoting function of PARD 3 by modulating the Hippo pathway signaling in response to cell contact and cell polarity signals.

PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein

TLDR
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USP21 regulates Hippo pathway activity by mediating MARK protein turnover.

TLDR
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PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ*

TLDR
PP1 as a bona fide TAZ phosphatase is identified and PP1A and ASPP2 play a critical role in promoting TAZ function by antagonizing the LATS kinase through TAZ dephosphorylation.

Regulation of YAP and TAZ Transcription Co-activators

The Yes-associated protein (YAP) and WW domain-containing ­transcrip­tion regulator 1 (WWTR1, also known as TAZ) are two transcription co-activators that act downstream of the Hippo tumor suppressor

The nonreceptor tyrosine kinase c-Src attenuates SCF(β-TrCP) E3-ligase activity abrogating Taz proteasomal degradation

TLDR
It is found that Src attenuates the SCF(β-TrCP) E3-ligase activity in blunting Taz proteasomal degradation, ruling out Taz modification as a mechanism of escaping degradation.
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