The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*

@article{Liu2010TheHT,
  title={The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase*},
  author={Chen-Ying Liu and Zheng-Yu Zha and Xin Zhou and Heng Zhang and W. Huang and D. Zhao and T. Li and S. W. Chan and C. J. Lim and W. Hong and S. Zhao and Y. Xiong and Q. Lei and K. Guan},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={37159 - 37169}
}
  • Chen-Ying Liu, Zheng-Yu Zha, +11 authors K. Guan
  • Published 2010
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • The TAZ transcription co-activator promotes cell proliferation and epithelial-mesenchymal transition. TAZ is inhibited by the Hippo tumor suppressor pathway, which promotes TAZ cytoplasmic localization by phosphorylation. We report here that TAZ protein stability is controlled by a phosphodegron recognized by the F-box protein β-TrCP and ubiquitylated by the SCF/CRL1β-TrCP E3 ligase. The interaction between TAZ and β-TrCP is regulated by the Hippo pathway. Phosphorylation of a phosphodegron in… CONTINUE READING
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