The Hin recombinase assembles a tetrameric protein swivel that exchanges DNA strands

@inproceedings{Dhar2009TheHR,
  title={The Hin recombinase assembles a tetrameric protein swivel that exchanges DNA strands},
  author={Gautam Dhar and Meghan M. McLean and John K. Heiss and Reid C Johnson},
  booktitle={Nucleic acids research},
  year={2009}
}
Most site-specific recombinases can be grouped into two structurally and mechanistically different classes. Whereas recombination by tyrosine recombinases proceeds with little movements by the proteins, serine recombinases exchange DNA strands by a mechanism requiring large quaternary rearrangements. Here we use site-directed crosslinking to investigate the conformational changes that accompany the formation of the synaptic complex and the exchange of DNA strands by the Hin serine recombinase… CONTINUE READING
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