The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

@inproceedings{Xiong2012TheHU,
  title={The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein},
  author={Xin Xiong and Yan Hao and Kan Sun and Jiaxing Li and Xia Li and Bibhudatta Mishra and Pushpanjali Soppina and Chunlai Wu and Richard I. Hume and Catherine A Collins},
  booktitle={PLoS biology},
  year={2012}
}
Axonal degeneration is a hallmark of many neuropathies, neurodegenerative diseases, and injuries. Here, using a Drosophila injury model, we have identified a highly conserved E3 ubiquitin ligase, Highwire (Hiw), as an important regulator of axonal and synaptic degeneration. Mutations in hiw strongly inhibit Wallerian degeneration in multiple neuron types and developmental stages. This new phenotype is mediated by a new downstream target of Hiw: the NAD+ biosynthetic enzyme nicotinamide… CONTINUE READING
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