The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas.

  title={The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas.},
  author={Palma Finelli and Giovanna Maria Pierantoni and Daniela Giardino and Marco Losa and Ornella Rodeschini and Monica Fedele and Emanuele Valtorta and Pietro Mortini and Carlo M. Croce and L Larizza and Alfredo Fusco},
  journal={Cancer research},
  volume={62 8},
Trisomy of chromosome 12 is a nonrandom chromosomal change in pituitary adenomas, particularly prolactinomas. This and the finding that prolactin-secreting pituitary adenomas develop in transgenic mice overexpressing the wild-type HMGA2 gene (which maps to 12q14-15) prompted us to investigate HMGA2 rearrangements and expression in human prolactinomas. By dual-color interphase fluorescence in situ hybridization analysis using HMGA2-specific PACs and BACs, we found that the HMGA2 locus was… CONTINUE READING


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