The Heuristic Refinement Method for Deriving Solution Structures of Proteins

Abstract

A new method is presented for determining structures of proteins in solution. The method uses constraints inferred from analytic data to successively refine both the locations for parts of the structure and the levels of detail for describing those parts. A computer program, called PROTEAN, which encodes this method, has been partially implemented and was used to derive structures for the lac-repressor headpiece from experimental data.

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Cite this paper

@inproceedings{Buchanan1998TheHR, title={The Heuristic Refinement Method for Deriving Solution Structures of Proteins}, author={Bruce G. Buchanan and Barbara Hayes-Roth and Olivicr Lichtarge and Russ B. Altman and Craig Cornelius and Bruce S. Duncan and Olivier Lichtarge and James F. Brinkley and Oleg Jardetzky and Micheal Hewett}, year={1998} }