The Heterotaxy Gene CCDC11 is Essential for Cytokinesis and Cell-Cell Adhesion via RhoA Regulation

@article{Kulkarni2018TheHG,
  title={The Heterotaxy Gene CCDC11 is Essential for Cytokinesis and Cell-Cell Adhesion via RhoA Regulation},
  author={Saurabh S Kulkarni and Rachel E. Stephenson and S. F. A. Amalraj and Ewelina Betleja and James J. Moresco and John R. Yates and Moe R Mahjoub and Ann L. Miller and Mustafa K. Khokha},
  journal={bioRxiv},
  year={2018}
}
Mutations in CCDC11 have been identified in multiple patients with heterotaxy (Htx), a disorder of left-right (LR) patterning of the internal organs. In Xenopus, depletion of Ccdc11 causes defects in LR patterning, recapitulating the patient phenotype. Upon Ccdc11 depletion, normally monociliated cells of the Left-Right Organizer (LRO) exhibit multiple cilia per cell. Unexpectedly, we found that Ccdc11 is necessary for successful cytokinesis, and the multiciliation observed in Ccdc11-depleted… Expand
2 Citations
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