The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis

@inproceedings{Hrlimann2016TheHA,
  title={The Heterodimeric ABC Transporter EfrCD Mediates Multidrug Efflux in Enterococcus faecalis},
  author={Lea M. H{\"u}rlimann and Valentina Corradi and Michael Hohl and Guido Vincent Bloemberg and D. Peter Tieleman and Markus A Seeger},
  booktitle={Antimicrobial agents and chemotherapy},
  year={2016}
}
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are poorly studied in this Gram-positive pathogen. In this study, we functionally investigated seven heterodimeric ABC transporters of E. faecalis that are annotated as drug efflux pumps. Deletion of ef0789-ef0790 on the chromosome of E. faecalis resulted in increased susceptibility to daunorubicin, doxorubicin, ethidium, and Hoechst 33342, and… CONTINUE READING
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