The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.

@article{Baranovich2016TheHS,
  title={The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.},
  author={Tatiana Baranovich and Jeremy C. Jones and Marion Russier and Peter Vogel and Kristy J. Szretter and Susan E. Sloan and Patrick Seiler and Jose M. Trevejo and Richard R. J. Webby and Elena A Govorkova},
  journal={Antimicrobial agents and chemotherapy},
  year={2016},
  volume={60 4},
  pages={2118-31}
}
Most cases of severe influenza are associated with pulmonary complications, such as acute respiratory distress syndrome (ARDS), and no antiviral drugs of proven value for treating such complications are currently available. The use of monoclonal antibodies targeting the stem of the influenza virus surface hemagglutinin (HA) is a rapidly developing strategy for the control of viruses of multiple HA subtypes. However, the mechanisms of action of these antibodies are not fully understood, and… CONTINUE READING