The Helicobacter pylori pyrB gene encoding aspartate carbamoyltransferase is essential for bacterial survival.

Abstract

The production of defined isogenic Helicobacter pylori pyrB mutants was undertaken to investigate the role of aspartate carbamoyltransferase (encoded by pyrB) in the survival of the bacterium. The complete structural gene for aspartate carbamoyltransferase from H. pylori strain RU1 was cloned into Escherichia coli by complementation of a pyrB auxotrophic… (More)

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@article{Burns2000TheHP, title={The Helicobacter pylori pyrB gene encoding aspartate carbamoyltransferase is essential for bacterial survival.}, author={Brendan Burns and Steven Hazell and George Louis Mendz and Tassia Kolesnikow and D M Tillet and Brett A Neilan}, journal={Archives of biochemistry and biophysics}, year={2000}, volume={380 1}, pages={78-84} }