The Hedgehog pathway as a drug target in cancer therapy.

  title={The Hedgehog pathway as a drug target in cancer therapy.},
  author={Matthias Lauth and Rune Toftg{\aa}rd},
  journal={Current opinion in investigational drugs},
  volume={8 6},
As with other developmentally important signaling pathways such as Wnt, TGF or Notch signaling, the Hedgehog (Hh) pathway has been shown to play an important role in the formation of several tumor types, including pancreas, prostate, skin and brain cancer. As the prognosis for some of these cancers is still poor, the Hh pathway may represent a novel drug target with high therapeutic potential. This review describes the mechanisms of signal transduction of the Hh pathway and the alterations that… CONTINUE READING

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