The Hedgehog Receptor Patched1 in T Cells Is Dispensable for Adaptive Immunity in Mice

@inproceedings{Michel2013TheHR,
  title={The Hedgehog Receptor Patched1 in T Cells Is Dispensable for Adaptive Immunity in Mice},
  author={Kai D. Michel and Anja Uhmann and Ralf Dressel and Jens van den Brandt and H. George Hahn and Holger M. Reichardt},
  booktitle={PloS one},
  year={2013}
}
Hedgehog (Hh) signaling modulates T cell development and function but its exact role remains a matter of debate. To further address this issue we made use of conditional knock-out mice in which the Hh receptor Patched1 (Ptch) is inactivated in the T cell lineage. Thymocyte development was moderately compromised by the deletion of Ptch as characterized by reduced numbers of CD4 and CD8 single-positive cells. In contrast, peripheral T cells were not affected. Proliferation and IFNγ secretion by… CONTINUE READING
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