The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)

Abstract

Anthrax lethal toxin (LT) induces vascular insufficiency in experimental animals through unknown mechanisms. In this study, we show that neuronal nitric oxide synthase (nNOS) deficiency in mice causes strikingly increased sensitivity to LT, while deficiencies in the two other NOS enzymes (iNOS and eNOS) have no effect on LT-mediated mortality. The increased… (More)
DOI: 10.1371/journal.ppat.1000456

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Cite this paper

@inproceedings{Moayeri2009TheHI, title={The Heart Is an Early Target of Anthrax Lethal Toxin in Mice: A Protective Role for Neuronal Nitric Oxide Synthase (nNOS)}, author={Mahtab Moayeri and D A Crown and David W T Dorward and Don Gardner and Jerrold M. Ward and Yan Li and Xizhong Cui and Peter Q Eichacker and Stephen H Leppla}, booktitle={PLoS pathogens}, year={2009} }