The Head Domain of Plakophilin-1 Binds to Desmoplakin and Enhances Its Recruitment to Desmosomes

@article{Kowalczyk1999TheHD,
  title={The Head Domain of Plakophilin-1 Binds to Desmoplakin and Enhances Its Recruitment to Desmosomes},
  author={A. Kowalczyk and M. Hatzfeld and E. Bornslaeger and D. S. Kopp and J. Borgwardt and C. Corcoran and A. Settler and K. Green},
  journal={The Journal of Biological Chemistry},
  year={1999},
  volume={274},
  pages={18145 - 18148}
}
The contribution of desmosomes to epidermal integrity is evident in the inherited blistering disorder associated with the absence of a functional gene for plakophilin-1. To define the function of plakophilin-1 in desmosome assembly, interactions among the desmosomal cadherins, desmoplakin, and the armadillo family members plakoglobin and plakophilin-1 were examined. In transient expression assays, plakophilin-1 formed complexes with a desmoplakin amino-terminal domain and enhanced its… Expand
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