The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

@article{Riley1998TheHB,
  title={The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis},
  author={Pual Riley and Lynn Anaon-Cartwight and James C Cross},
  journal={Nature Genetics},
  year={1998},
  volume={18},
  pages={271-275}
}
The placenta and cardiovascular system are the first organ systems to form during mammalian embryogenesis. We show here that a single gene is critical for development of both. The Hand1 gene, previously called Hxt, eHAND and Thingl, encodes a basic helix-loop-helix (bHLH) transcription factor that starts to be expressed during pre-implantation development. After implantation, Handl expression is restricted to placental trophoblast cells and later to embryonic cardiac and neural crest cells1–3… CONTINUE READING
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