The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells.

@article{Hughes2004TheHS,
  title={The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells.},
  author={Martha Hughes and Nikolina Dobric and Ian C Scott and Lin Su and Maja Starovic and Benoit St-Pierre and Sean E. Egan and John C. P. Kingdom and James C Cross},
  journal={Developmental biology},
  year={2004},
  volume={271 1},
  pages={26-37}
}
The trophoblast cell lineage is an interesting model system because it is composed of a limited number of cell types that are spatially patterned. Trophoblast stem (TS) cells reside within a layer called the chorion and either remain as stem cells or differentiate into spongiotrophoblast (SpT), trophoblast giant (TG) cells or syncytiotrophoblast cells (SynT) of the labyrinth. Maintenance of the TS phenotype is dependent on stimulation by FGF4, whereas differentiation and/or maintenance of the… CONTINUE READING
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