MECHANISMS OF DISEASE
- Biology, Medicine
Recent successes in the experimental transformation of human cells indicate that the disruption of a limited number of cellular regulatory pathways is sufficient to impart a tumorigenic phenotype to a wide variety of normal cells, suggesting a series of genetic and cellular principles that may govern the formation of most, if not all, types of human cancers.
SCRIBBLE: A POTENTIAL DUAL KINASE INHIBITOR
The primary investigator, friend, and mentor, Dr Hiroshi Miyazaki, was the backbone of the authors' lab, helping in any imaginable way, from the little things to the big, and his persistence in the laboratory stood out the most.
Lipid rafts, death receptors and CASMERs: new insights for cancer therapy.
- ChemistryFuture oncology
This work was supported by grants from ministerio de Ciencia e Innovacion, Red Tematica de Investigacion Cooperativa en Cancer, Instituto de Salud Carlos III and European Commission.
A Joint Odyssey into Cancer Genetics
- BiologyAnnual Review of Cancer Biology
The war on cancer that began some 40 years ago with the discovery of oncogenes is starting to be won, and it is encouraging hope that many more malignancies will become controllable and even curable.
The evolution of the biomedical paradigm in oncology: implications for cancer therapy.
- MedicineAdvances in experimental medicine and biology
Harold Varmus’ analysis joins the increasing attacks on cancer research policy inspired by the U.S. President Richard Nixon’s National Cancer Act of December 1971, declaring the “war on cancer”.
implicates osteopontin as a functional prognostic factor in AML Expression profiling of a hemopoietic cell survival transcriptome
It is necessary to select patients suitable for blood donation based on prior history and once they provide informed consent for surgery, the likelihood of adverse events and the importance of avoiding unnecessary surgery is investigated.
The impact of phosphatases on proliferative and survival signaling in cancer
- BiologyCellular and Molecular Life Sciences
The role of phosphatases in the regulation of cellular proliferation and survival signaling is discussed using the examples of the MAPK and PI3K/AKT pathways, c-Myc and the apoptosis machinery to favor growth and persistence of human cancer.
SHOWING 1-10 OF 194 REFERENCES
Mortality and immortality at the cellular level. A review.
- BiologyBiochemistry. Biokhimiia
Telomere shortening and the finite lifetime of normal cells is more likely to represent longevity determination than it is aging, and the hundreds of biological changes that herald the loss of replicative capacity in normal cells are more likely age changes.
p53 tumor suppressor gene: from the basic research laboratory to the clinic--an abridged historical perspective.
The 16 year history of p53 investigations is a paradigm in cancer research, illustrating the convergence of previously parallel lines of basic, clinical, and epidemiologic investigation and the rapid transfer of research findings from the laboratory to the clinic.
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
- BiologyProceedings of the National Academy of Sciences of the United States of America
A series of publications over the past year now suggest a mechanism by which PTEN loss of function results in tumors, and PTEN appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell growth and survival by dephosphorylating the 3 position ofosphoinositides.
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.
Transfection assays indicate that, in fibroblasts, wild-type p53 inhibits angiogenesis through regulation of TSP-1 synthesis.
Landscaping the Cancer Terrain
The gene defective in one of the inherited syndromes is SMAD4, a member of a key signal transduction pathway that has an indirect effect on the tissue that will eventually become cancerous and create an abnormal microenvironment for the cells, probably by acting in the adjacent stromal cells.