The Hallmarks of Aging

  title={The Hallmarks of Aging},
  author={Carlos L{\'o}pez-Ot{\'i}n and Mar{\'i}a A. Blasco and Linda Partridge and Manuel Serrano and Guido Kroemer},

Figures from this paper

Mitotic Dysfunction Associated with Aging Hallmarks.
Based on the evidence, a mutual causality between aging and aneuploidy is proposed, and modulation of mitotic fidelity is suggested as a potential means to ameliorate healthy lifespan.
Implications of Sphingolipids on Aging and Age-Related Diseases
The major contributions of sphingolipids to the hallmarks of aging and age-related diseases are discussed while also summarizing the importance of their other minor but integral contributions.
Regulatory Roles of miRNAs in Aging.
The description of the diverse functional roles of geromiRs, the large and growing subgroup of miRNAs implicated in aging, will be described and potential strategies for managing aging and extending longevity based on geromiR modulation are discussed.
mTOR and Aging: An Old Fashioned Dress
The role of mTor signalling network in the development of classic age-related diseases, focused on cardiovascular system, immune response, and cancer is discussed.
The Biology of Aging and Cancer: A Brief Overview of Shared and Divergent Molecular Hallmarks
It is now clear that aging and cancer development either share or diverge in several disease mechanisms, and aging can be considered an aging disease, though the shared mechanisms underpinning the two processes remain unclear.
Aging: Molecular Pathways and Implications on the Cardiovascular System
It is possible to draw a common pathway unifying aging to cardiovascular diseases, and the central point of this process, senescence, can be the target for new therapies, which may result in the healthspan matching the lifespan.
The Mitochondrial Basis of Aging and Age-Related Disorders
The current understanding on how mitochondrial functional decline contributes to aging is reviewed, including the role of somatic mitochondrial DNA mutations, reactive oxygen species (ROS), mitochondrial dynamics and quality control pathways, and the emerging evidence on how dysregulated mitochondrial dynamics, mitochondrial biogenesis and turnover mechanisms contribute to the pathogenesis of age-related disorders.
Aging, Cellular Senescence, and Progressive Multiple Sclerosis
The evidence linking cellular senescence to the pathogenesis of MS and the putative role of senolytic and senomorphic agents as neuroprotective therapies in tackling disease progression are discussed.


The Critical Role of Metabolic Pathways in Aging
A special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans, and recent advances in the understanding of the complex role of metabolic pathways in the aging process are discussed.
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Mitochondrial longevity pathways.
Genetics of longevity in model organisms: debates and paradigm shifts.
Central concepts about the nature of aging are reexamine, including the hyperfunction theory, which postulates that processes contributing to growth and reproduction run on in later life, leading to hypertrophic and hyperplastic pathologies.
DNA damage, aging, and cancer.
  • J. Hoeijmakers
  • Biology, Medicine
    The New England journal of medicine
  • 2009
Evidence that cancer and diseases of aging are two sides of the DNAdamage problem is presented, followed by an account of the derailment of genome guardian mechanisms in cancer and of how this cancerspecific phenomenon can be exploited for treatment.
The aging stress response.
Genome-Environment Interactions That Modulate Aging: Powerful Targets for Drug Discovery
A broad range of findings in model organisms are reviewed, from environmental to genetic manipulations of aging, with a focus on those with underlying gene-environment interactions with potential for drug discovery and development.
The microRNA miR-34 modulates aging and neurodegeneration in Drosophila
It is reported that the conserved miRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted ancestral humans to energetically adapt to their ancestral homes are influencing their health today.
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan.