The HSP90 chaperone machinery

@article{Schopf2017TheHC,
  title={The HSP90 chaperone machinery},
  author={Florian H. Schopf and Maximilian M. Biebl and Johannes Buchner},
  journal={Nature Reviews Molecular Cell Biology},
  year={2017},
  volume={18},
  pages={345-360}
}
The heat shock protein 90 (HSP90) chaperone machinery is a key regulator of proteostasis under both physiological and stress conditions in eukaryotic cells. As HSP90 has several hundred protein substrates (or 'clients'), it is involved in many cellular processes beyond protein folding, which include DNA repair, development, the immune response and neurodegenerative disease. A large number of co-chaperones interact with HSP90 and regulate the ATPase-associated conformational changes of the HSP90… CONTINUE READING
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