The HPLC determination of propane-1,2,3-triyl trinitrite and impurities: (2RS)-3-hydroxypropane-1,2-diyl dinitrate and 2-hydroxypropane-1,3-diyl dinitrate in ointment.

@article{Krzek2003TheHD,
  title={The HPLC determination of propane-1,2,3-triyl trinitrite and impurities: (2RS)-3-hydroxypropane-1,2-diyl dinitrate and 2-hydroxypropane-1,3-diyl dinitrate in ointment.},
  author={Jan Krzek and Maria Moniczewska and Grazyna Zabierowska-Slusarczyk},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2003},
  volume={33 3},
  pages={403-9}
}
A HPLC method for determination of propane-1,2,3-triyl trinitrate and impurities: (2RS)-3-hydroxypropane-1,2-diyl dinitrate and 2-hydroxypropane-1,3-diyl dinitrate ointment was developed. The conditions for good separation of constituents, while avoiding vehiculum interference were established. The results feature of high accuracy and good precision. For individual constituents R.S.D. is ranged from 0.7 to 9.9%, while recovery was 100.1% for propane-1,2,3-triyl trinitrate and 95.1-99.0% for… CONTINUE READING