The HPA axis and the genesis of chronic fatigue syndrome

@article{Cleare2004TheHA,
  title={The HPA axis and the genesis of chronic fatigue syndrome},
  author={A. Cleare},
  journal={Trends in Endocrinology & Metabolism},
  year={2004},
  volume={15},
  pages={55-59}
}
  • A. Cleare
  • Published 2004
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • Many studies of patients with long-standing chronic fatigue syndrome (CFS) have found alterations to the hypothalamo-pituitary-adrenal (HPA) axis, including mild hypocortisolism, heightened negative feedback and blunted responses to challenge. However, recent prospective studies of high-risk cohorts suggest that there are no HPA axis changes present during the early stages of the genesis of fatiguing illnesses. Moreover, HPA axis changes can be reversed by modifying behavioural features of the… CONTINUE READING
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