The HPA axis and the genesis of chronic fatigue syndrome

@article{Cleare2004TheHA,
  title={The HPA axis and the genesis of chronic fatigue syndrome},
  author={Anthony J. Cleare},
  journal={Trends in Endocrinology \& Metabolism},
  year={2004},
  volume={15},
  pages={55-59}
}
  • A. Cleare
  • Published 1 March 2004
  • Psychology
  • Trends in Endocrinology & Metabolism

Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome

There is evidence for a hypofunction of the hypothalamic-pituitary-adrenal (HPA) axis in a proportion of the patients with chronic fatigue syndrome (CFS), despite the negative studies and

Hypothalamic–pituitary–adrenal axis dysfunction in chronic fatigue syndrome

The weight of current evidence supports the presence of the following factors related to hypothalamic–pituitary–adrenal (HPA) axis dysfunction in patients with chronic fatigue syndrome (CFS): mild

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TLDR
Given the interindividual variation in the effectiveness of existing biological and psychological treatments, the need for novel treatment strategies such as those which target the HPA axis is clear.

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TLDR
There is no structural abnormality in the endocrine organs which comprise the HPA axis, thus it seems that hypocortisolemia found in the patients with stress-related disorder is functional.

Neuroendocrine disorder in chronic fatigue syndrome

TLDR
One-time hormone measurement is not sufficient to detect hormonal imbalance in women suffering from CFS, and absence of a correlation between afternoon and morning cortisol level could be a more representative factor for detecting HPA axis disturbance.

Childhood stressors in the development of fatigue syndromes: a review of the past 20 years of research

TLDR
Exposure to childhood stressors is associated with the subsequent development of fatigue syndromes such as CFS and FM, and related symptoms, and further studies are needed to identify the mechanisms underlying these associations.

Commonalities in the Features of Cancer and Chronic Fatigue Syndrome (CFS): Evidence for Stress-Induced Phenotype Instability?

Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cancer-Related Fatigue (CRF) are syndromes with considerable overlap with respect to symptoms. There have been many studies that have

Chronic fatigue syndrome.

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Neuroendocrine and Immune Contributors to Fatigue

...

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