The HPA axis and the genesis of chronic fatigue syndrome

@article{Cleare2004TheHA,
  title={The HPA axis and the genesis of chronic fatigue syndrome},
  author={Anthony J. Cleare},
  journal={Trends in Endocrinology \& Metabolism},
  year={2004},
  volume={15},
  pages={55-59}
}
  • A. Cleare
  • Published 1 March 2004
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
Many studies of patients with long-standing chronic fatigue syndrome (CFS) have found alterations to the hypothalamo-pituitary-adrenal (HPA) axis, including mild hypocortisolism, heightened negative feedback and blunted responses to challenge. However, recent prospective studies of high-risk cohorts suggest that there are no HPA axis changes present during the early stages of the genesis of fatiguing illnesses. Moreover, HPA axis changes can be reversed by modifying behavioural features of the… 
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Chronic fatigue syndrome.
  • L. Devanur, J. Kerr
  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2006
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Current priorities are to understand the molecular pathogenesis of disease in terms of human and virus gene expression, to develop a diagnostic test based on protein biomarkers, and to develop specific curative treatments.
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