The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.

  title={The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.},
  author={Alejandra Loyola and Hideaki Tagami and Tiziana Bonaldi and Dani{\`e}le M.J. Roche and Jean Pierre Quivy and Axel Imhof and Yoshihiro Nakatani and Sharon Y. R. Dent and Genevi{\`e}ve Almouzni},
  journal={EMBO reports},
  volume={10 7},
Trimethylation of lysine 9 in histone H3 (H3K9me3) enrichment is a characteristic of pericentric heterochromatin. The hypothesis of a stepwise mechanism to establish and maintain this mark during DNA replication suggests that newly synthesized histone H3 goes through an intermediate methylation state to become a substrate for the histone methyltransferase Suppressor of variegation 39 (Suv39H1/H2). How this intermediate methylation state is achieved and how it is targeted to the correct place at… CONTINUE READING
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Loss of the Suv 39 h histone methyltransferases impairs mammalian heterochromatin and genome stability

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