The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration.

@article{Gdynia2016TheHP,
  title={The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration.},
  author={Georg Gdynia and Sven Wolfgang Sauer and J{\"u}rgen Kopitz and Dominik Fuchs and Katarina Duglova and Thorsten Ruppert and Matthias Miller and Jens H. W. Pahl and Adelheid Cerwenka and Markus Enders and Heimo Mairb{\"a}url and Marcin Mikołaj Kamiński and Roland Penzel and Christine S Zhang and Jonathan C. Fuller and Rebecca C. Wade and Axel Benner and Jenny Chang-Claude and Hermann Brenner and Michael Hoffmeister and H. Zentgraf and Peter Schirmacher and Wilfried Roth},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={10764}
}
The high-mobility group box 1 (HMGB1) protein has a central role in immunological antitumour defense. Here we show that natural killer cell-derived HMGB1 directly eliminates cancer cells by triggering metabolic cell death. HMGB1 allosterically inhibits the tetrameric pyruvate kinase isoform M2, thus blocking glucose-driven aerobic respiration. This results in a rapid metabolic shift forcing cells to rely solely on glycolysis for the maintenance of energy production. Cancer cells can acquire… CONTINUE READING