The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

@article{Wilson2005TheHB,
  title={The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.},
  author={Maria E. Wilson and Katherine Y Yang and Anna Kalousova and Janet Lau and Yasuhiro Kosaka and Francis C Lynn and Juehu Wang and Caroline Mrejen and Vasso Episkopou and Hans Clevers and Michael S. German},
  journal={Diabetes},
  year={2005},
  volume={54 12},
  pages={3402-9}
}
To investigate the role of the Sry/hydroxymethylglutaryl box (Sox) transcription factors in the development of the pancreas, we determined the expression pattern of Sox factors in the developing mouse pancreas. By RT-PCR, we detected the presence of multiple Sox family members in both the developing pancreas and mature islets and then focused on two factors, Sox2 and Sox4. The expression field of Sox2, which plays a role in the maintenance of some stem cell populations, included the developing… CONTINUE READING