The HLF/IL-6/STAT3 feedforward circuit drives hepatic stellate cell activation to promote liver fibrosis.

Abstract

BACKGROUND AND AIMS Liver fibrosis is a wound-healing response that disrupts the liver architecture and function by replacing functional parenchyma with scar tissue. Recent progress has advanced our knowledge of this scarring process, but the detailed mechanism of liver fibrosis is far from clear. METHODS The fibrotic specimens of patients and HLF… (More)
DOI: 10.1136/gutjnl-2016-313392

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