The HLA-DRw8 lineage was generated by a deletion in the DR B region followed by first domain diversification.

@article{Gorski1989TheHL,
  title={The HLA-DRw8 lineage was generated by a deletion in the DR B region followed by first domain diversification.},
  author={Jack Gorski},
  journal={Journal of immunology},
  year={1989},
  volume={142 11},
  pages={4041-5}
}
Sequences were generated for the first, second, and 3'UT regions of DRw8 beta-chain genes from two cell lines differing in their T cell determined allospecificities. Both have second domain sequences homologous to the B1 locus of the DRw52 family (DR3, DR5, and DRw6) and not the B3 locus. However, the 3'UT sequence is homologous to the 3'UT region of the B3 locus of the DRw52 family, and not the B1 locus. The first domain sequences are B1-like as opposed to B3-like and show polymorphism in the… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Similar Papers

Loading similar papers…