The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.

@article{Mil2007TheHS,
  title={The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.},
  author={Annette H van der Helm-van Mil and Kirsten N. Verpoort and Saskia le Cessie and Tom W. J. Huizinga and Rene Penning de Vries and Ren{\'e} E M Toes},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 2},
  pages={425-32}
}
OBJECTIVE The HLA shared epitope (SE) alleles are primarily a risk factor for the presence of antibodies to cyclic citrullinated peptide (anti-CCP antibodies) rather than for the development of rheumatoid arthritis (RA). The SE alleles interact with the environmental risk factor tobacco exposure (TE) for predisposition to anti-CCP+ RA. The objectives of this study were to determine 1) whether different SE subtypes contribute differently to the presence of anti-CCP antibodies, 2) whether… CONTINUE READING