The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes.

@article{Battelino2003TheH,
  title={The HLA-DRB, -DQB polymorphism and anti-insulin antibody response in Slovenian patients with type 1 diabetes.},
  author={Tadej Battelino and Natasa Ursic-Bratina and Vita Dol{\vz}an and Mirjam Stopar-Obreza and Paolo Pozzilli and Ciril Kr{\vz}i{\vs}nik and Blanka Vidan-Jeras},
  journal={European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics},
  year={2003},
  volume={30 3},
  pages={223-7}
}
A combination of specific HLA class II antigens and the presence of type 1 diabetes (T1D)-related antibodies has a high positive predictive value for T1D but low sensitivity. The aim of the present study was to determine the frequencies of HLA-DRB-DQB deduced haplotypes associated with susceptibility and protection in Slovenian patients with established T1D, to evaluate the relationship between the HLA-DRB1-QBP-DQB1 haplotypes and the presence of insulin autoantibodies (IAA) and glutamic acid… CONTINUE READING