The HLA-A mutation assay: improved technique and normal results.

@article{McCarron1989TheHM,
  title={The HLA-A mutation assay: improved technique and normal results.},
  author={M. McCarron and A. Kutlaca and A. Morley},
  journal={Mutation research},
  year={1989},
  volume={225 4},
  pages={
          189-93
        }
}
The HLA-A assay for detection of mutant lymphocytes has been modified, principally by incorporation of an overnight-incubation step which has resulted in improved immunoselection. For 83 estimations on cells from 21 normal individuals with a mean age of 35, the in vivo mutant frequency was 2.99 X 10(-5) +/- 1.48 X 10(-5) (mean +/- 1 SD). For 11 estimations on cells from 10 elderly individuals with a mean age of 78, the mutant frequency was significantly greater, being 7.16 X 10(-5) +/- 4.06 X… Expand
Classification of mutations at the HLA‐A locus by use of the polymerase chain reaction
In vivo mutations at the H-2 locus in mouse lymphocytes.
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