The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.

@article{Cujec1997TheHT,
  title={The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II.},
  author={Thomas P Cujec and Harumasa Okamoto and Koh Fujinaga and Johann Meyer and H A Chamberlin and David O. Morgan and Boris Matija Peterlin},
  journal={Genes & development},
  year={1997},
  volume={11 20},
  pages={2645-57}
}
The human immunodeficiency virus encodes the transcriptional transactivator Tat, which binds to the transactivation response (TAR) RNA stem-loop in the viral long terminal repeat (LTR) and increases rates of elongation rather than initiation of transcription by RNA polymerase II (Pol II). In this study, we demonstrate that Tat binds directly to the cyclin-dependent kinase 7 (CDK7), which leads to productive interactions between Tat and the CDK-activating kinase (CAK) complex and between Tat and… CONTINUE READING
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