The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling.

@article{Wang2004TheHP,
  title={The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling.},
  author={Michael W-H Wang and Shi Gao Wei and Roberta Faccio and Sunao Takeshita and Pablo Tebas and William G. Powderly and Steven L Teitelbaum and Frederick Ross},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={114 2},
  pages={206-13}
}
Highly active antiretroviral therapy (HAART), which includes HIV protease inhibitors (PIs), has been associated with bone demineralization. To determine if this complication reflects accelerated resorptive activity, we studied the impact of two common HIV PIs, ritonavir and indinavir, on osteoclast formation and function. Surprisingly, we find that ritonavir, but not indinavir, inhibits osteoclast differentiation in a reversible manner and also abrogates bone resorption by disrupting the… CONTINUE READING

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