Corpus ID: 39833693

The HIV coreceptors CXCR 4 and CCR 5 are differentially expressed and regulated on human T lymphocytes

@inproceedings{Bleul1997TheHC,
  title={The HIV coreceptors CXCR 4 and CCR 5 are differentially expressed and regulated on human T lymphocytes},
  author={C. Bleul and W. Li-jun and J. Hoxie and T. Springer and C. Mackay},
  year={1997}
}

C. Bleul, W. Li-jun, +2 authors C. Mackay

Published 1997

The chemokine receptors CXCR4 and CCR5 function as coreceptors for HIV-1 entry into CD41 cells. During the early stages of HIV infection, viral isolates tend to use CCR5 for viral entry, while later isolates tend to use CXCR4. The pattern of expression of these chemokine receptors on T cell subsets and their regulation has important implications for AIDS pathogenesis and lymphocyte recirculation. A mAb to CXCR4, 12G5, showed partial inhibition of chemotaxis and calcium influx induced by SDF-1… CONTINUE READING

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