The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions.

@article{Foti1999TheHN,
  title={The HIV Nef protein alters Ca(2+) signaling in myelomonocytic cells through SH3-mediated protein-protein interactions.},
  author={Michelangelo Foti and Laetitia Cartier and Vincent Piguet and Daniel P. Lew and J. Carpentier and Didier Trono and Karl Heinz Krause},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 49},
  pages={34765-72}
}
Human immunodeficiency virus Nef plays an important role in AIDS pathogenesis. In addition to the well known down-regulation of cell surface receptors (CD4, MHCI), Nef is able to alter cellular signaling. Of particular interest for this study is the ability of Nef to bind with a very high affinity to SH3 domains of myelomonocyte-specific protein-tyrosine kinases of the Src family (Src-like PTK). We have therefore investigated Ca(2+) signaling in HL60 cells retrovirally transduced with wild type… CONTINUE READING
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