The HIV-2 Vpx protein usurps the Cul4A-DDB1-DCAF1 ubiquitin ligase to overcome a post-entry block in macrophage infection

@article{Ayinde2009TheHV,
  title={The HIV-2 Vpx protein usurps the Cul4A-DDB1-DCAF1 ubiquitin ligase to overcome a post-entry block in macrophage infection},
  author={Diana Ayinde and Anna Bergamaschi and Annie David and Erwann Le Rouzic and Marina Morel and S{\'e}bastien Nisole and Florence Margottin-Goguet and Gianfranco Pancino and Catherine Transy},
  journal={Retrovirology},
  year={2009},
  volume={6},
  pages={O16 - O16}
}
We have previously shown that HIV-1 Vpr induces cell cycle arrest by recruiting the CUL4A-DDB1DCAF1 ubiquitin ligase. This presumably leads to the degradation of a host factor required for cell cycle progression into mitosis. Vpr and Vpx proteins are evolutionary related and show significant sequence similarity even though they are not functionally redundant. This prompted us to address whether Vpx, like Vpr, recruits the CUL4A-DDB1DCAF1 ubiquitin ligase and whether Vpx uses this functional… CONTINUE READING