The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART.

@article{Peng2010TheHT,
  title={The HIV-1 transgenic rat as a model for HIV-1 infected individuals on HAART.},
  author={Jinsong Peng and Michael Vigorito and Xiangqian Liu and Dunjing Zhou and Xiongwen Wu and Sulie L. Chang},
  journal={Journal of neuroimmunology},
  year={2010},
  volume={218 1-2},
  pages={94-101}
}
HIV-1 viral replication is limited in patients given highly active anti-retroviral therapy (HAART); however, HIV-1 viral proteins are still present. We demonstrate that the developing HIV-1Tg rat, which expresses all of the HIV-1 viral genes except the gag-pol replication genes, maintains lower body weight compared with the F344 control rat. Although HIV-1Tg rats eat and drink less than the control animals, they are not anorexic and show no evidence of anhedonia. At 19 months (mo) of age, HIV… CONTINUE READING
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